Older Americans Independence Center
Publications

2004
Bjornsson HT, Cui H, Guis D, Fallin MD, Feinberg AP.  The New Field of Epigenomics: Implications for Cancer and Other Common Disease Research. Cold Spring Harb Symp Quant Biol. 2004: 69:447-56. PMID: 16117680.

Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 2004 Aug: 20(8):350-8. PMID: 15262407.

Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD (Interventions on Frailty Working Group).  Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report.  J Am Geriatr Soc. 2004 Apr;52(4):625-34. PMID: 15066083.

Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.  J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63. PMID: 15031310.

2005
Benke KS, Chase GA, Fallin D.  Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test.  BMC Genet. 2005 Dec 30;6 Suppl 1:S137. PMID: 16451596

Blaum CS, Xue Q-L, Michelon E, Semba RD, Fried LP. The association of obesity and the frailty syndrome in older women. The Journal of the American Geriatrics Society 2005 June; 53(6):927-34. PMID: 15935013.

Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu A.  Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases:  Implications for Pay for Performance.  JAMA, August 10, 2005:294:5:716-724. PMID: 16091574.

Boyd CM, Xue Q-L, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. The American Journal of Medicine, 2005 Nov;118(11):1225-31. PMID: 16271906.

Chaves PH, Semba RD, Leng SX, Woodman RC, Ferrucci L, Guralnik JM, Fried LP.  Impact of Anemia and Cardiovascular Disease on Frailty Status of Community-Dwelling Older Women: The Women’s Health and Aging Studies I and II.  J Gerontol Med Sci, 2005 June;60A:6:729-735. PMID: 15983175.

Fried LP, Hadley EC, Walston JD, Newman A, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L.  From bedside to bench: research agenda for frailty.  Sci Aging Knowledge Environ. 2005 Aug 3;2005(31):pe24. PMID: 16079413.

Leng SX, Xue Q-L, Huang Y, Ferrucci L, Beamer BA, Fried LP, Walston J.  Baseline Total and Specific Differential White Blood Cell Counts and 5-year All-Cause Mortality in Community-Dwelling Older Women. Experimental Gerontology, 2005 Dec, (40):982-987. PMID: 16183235.

Leng SX, Xue Q-L, Huang Y, Semba R, Chaves P, Bandeen-Roche K, Fried LP, Walston J. Total and differential WBC counts and their associations with circulating IL-6 levels in community-dwelling older women. J Gerontol Med Sci, 2005;60A:195-199.

Nicodemus KK, Liu W, Chase GA, Tsai YY, Fallin MD. Comparison of type I Error for Multiple Test Corrections in Large SNP Studies Using Principal Components Versus Haplotype Blocking Algorithms. BMC Genetics 2005 Dec: 6 Suppl 1:S78. PMID: 16451692

Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q, Ferrucci L, Fried LP, Chakravarti A. IL-6 Gene Variation is not Associated with Increased Serum Levels of IL-6, muscle weakness, or frailty in older women. Experimental Gerontology, 2005; 40:344-352. PMID: 15820616.

Wang C-P, Brown CH, Bandeen-Roche K.  Residual Diagnostics for Growth Mixture Models:  Examining the Impact of a Preventive Intervention on Multiple Trajectories of Aggressive Behavior.  Journal of the American Statistical Association, 2005 Sep;100(3):1054-1076.

Yuh DD, Baumgartner WA.  Cardiac Surgery in the Elderly.  In:  Gerstenblith G, ed.  Cardiovascular Disease in the Elderly.  Totowa, NJ, Humana Press, Inc.  2005 June: pp. 179-201.

2006
Arking DE, Fallin DM, Li T, Beamer BA, Xue QL, Fried LP, Chakravarti A, Walston JD. Variation in the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women. Journal of the American Geriatrics Society, 2006; May;54(5):823-6. PMID: 16696750.

Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, Chaves PHM, Zeger SL, Fried LP. Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. J Gerontol Med Sci, 2006 Mar;61(3):262-6. PMID: 16567375.

Bartali B, Frongillo EA, Bandinelli S, Lauretani F, Semba RD, Fried LP, Ferrucci L.  Low nutrient intake is an essential component of frailty in older persons.  J Gerontol: Med Sci. 2006 Jun;61(6):589-93. PMID: 16799141.

Chaves PHM, Carlson MC, Guralnik JM, Ferrucci L, Semba R, Fried LP.  Association of Mild Anemia with Executive Cognitive Function Impairment in Community-Dwelling Older Women: The Women’s Health and Aging Study II.  J Am Geriatr Soc. 2006 Sep;54(9):1429-35. PMID: 16970654.

Chi PB, Duggal P, Kao WH, Mathias RA, Grant AV, Stockton ML, Garcia JG, Ingersoll RG, Scott AF, Beaty TH, Barnes KC, Fallin MD. Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. Genet Epidemiol. 2006 Nov: 30(7):609-19. PMID: 16830339.

Kim DH, Lipsitz LA, Ferrucci L, Guralnik JM, Carlson M, Fleisher LA, Fried LP, Chaves PHM. Association of Reduced Heart Rate Variability with Cognitive Impairment in Older Disabled Women in the Community: A Pilot Study in the Women’s Health and Aging Study I.  J Am Geriatr Soc. 2006 Nov;54(11):1751-7. PMID: 17087704.

Ling SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM.  Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II. Arthritis Rheum. 2006 Apr 15;55(2): 256-63. PMID: 16583416.

Michelon E, Blaum C, Semba RD, Xue QL, Ricks MO, Fried LP.  Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):600-7. PMID: 16799143.

Studenski S, Carlson MC, Fillit H, Greenough WT, Kramer A, Rebok GW..  From bedside to bench: does mental and physical activity promote cognitive vitality in late life?  Sci Aging Knowledge Environ 2006. 28; (10): 21. PMID: 16807485.

Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults--The Experience Corps program in Baltimore. J Urban Health. 2006 Sep;83(5):954-69. PMID: 16763775.

Walston J, Hadley EC, Ferrucci L, Guralnik J, Newman, AB, Studenski S, Ershler W, Harris T, Fried LP.  Research agenda for Frailty in Older Adults: Towards a Better Understanding of Physiology and Etiology. J Am Geriatr Soc. 2006 Jun;54(6):991-1001. PMID: 16776798.

Walston J, Xue Q-L, Semba RD, Ferrucci L, Cappola AR, Ricks M, Guralnik JM, Fried LP. Serum Antioxidants, Inflammation, and Mortality in Older Women. American Journal of Epidemiology 2006:Jan1;163(1):18-26. PMID: 16306311.

2007
Barzilay JI, Blaum C, Moore T, Xue Q-L, Hirsch CH, Walston JD, Fried LP.  Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study. Arch Intern Med 2007; 167(7):635-41. PMID: 17420420.

Beck J, Ferrucci L, Sun K, Walston J, Fried LP, Varadhan R, Guralnik JM, Semba RD.  Low serum selenium concentrations are associated with poor grip strength among older women living in the community.  Biofactors. 2007;29(1):37-44.  PMID: 17611292.

Boyd CM, Weiss CO, Halter J, Han KC, Ershler WB, Fried LP: Framework for Evaluating Disease Severity Measures in Older Adults with Comorbidity. J Gerontol A Biol Sci Med Sci.  2007, Vol. 62A, No. 3, 286–295. PMID: 17389726.

Chang DC, Joyce DL, Shoher A, Yuh DD.  A Simple Index to Predict Likelihood of Skilled Nursing Facility Admission after CABG among Older Patients.  Ann Thorac Surg. 2007 Sep;84(3):829-34; discussion 834-5. PMID: 17720384

Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, Margolick JB; Multicenter AIDS Cohort Study. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1279-86.  PMID: 18000149.

Folsom AR, Boland LL, Cushman M, Heckbert SR, Rosamond WD, Walston JD.  Frailty and risk of venous thromboembolism in older adults.  J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):79-82. PMID: 15066083.

Howard C, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD. Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol. 2007 Jul;103(1):17-20. Epub 2007 Mar 22. PMID: 17379753.

Leng SX, Xue Q-L, Tian J, Walston J, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007 Jun;55(6):864-71. PMID: 17537086.

Rebok GW, Carlson MC, & Langbaum JB.  Training and maintaining memory abilities in healthy older adults: traditional and novel approaches. J Gerontol B Psychol Sci Soc Sci. 2007 Jun;62 Spec No 1:53-61. Review.  PMID: 17565165.

Roland C., Varadhan R., and Frangakis C.E. Squared polynomial extrapolation methods with cycling: an application to the positron emission tomography problem, Numerical Algorithms, Volume 44, Number 2, February 2007, pp. 159-172.

Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP.  Oxidative stress and severe walking disability among older women. Am J Med. 2007 Dec;120(12):1084-9. PMID: 18060930.

Semba RD, Ricks MO, Ferrucci L, Xue QL, Guralnik JM, Fried LP. Low serum selenium is associated with anemia among older adults in the United States. Eur J Clin Nutr. 2007 Sep 5; [Epub ahead of print]. PMID: 17805227.

Walston JD, Fallin MD, Cushman M, Lange L, Psaty B, Jenny N, Browner W, Tracy R, Durda P, Reiner A. IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. Hum Genet. 2007 Dec;122(5):485-94. Epub 2007 Sep 13. PMID: 17851695.

Weiss CO, Boyd CM, Yu Q, Wolff JL, Leff B.  Patterns of prevalent major chronic disease among older adults in the United States. JAMA. 2007 Sep 12;298(10):1160-2. PMID: 17848649.

2008
Carlson MC, Helms MJ, Steffens DC, Burke JR, Potter GG,Plassman BL. Mid-life Activity Predicts Risk of Alzheimer’s Disease in Older Male Twin Pairs.  Alzheimers and Dementia, 2008; 4:324-331.

Carlson MC, Xue QL, Zhou J, & Fried LP.  Declines in executive function precede those in memory in high functioning older women: The Women’s Health and Aging Study II. Neurology. (In press)

Dayhoff-Brannigan M, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD.  Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community. J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):179-83. PMID: 18314454

De Fanis U, Wang G, Fedarko N, Walston J, Casolaro V, and Leng SX. T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults.  J Am Geriatr Soc. 2008 May;56(5):904-8. Epub 2008 Apr 1. PMID: 18384587

Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue QL, Leng S, Beamer B, Walston JD. Glutathione peroxidase enzyme activity in aging. J Gerontol A Biol Sci Med Sci. 2008 May;63(5):505-9. PMID: 18511755

Evans WJ, Bhasin S, Cress C, Espeland MA, Ferrucci L, Fried LP, Gill G, Pahor M, Studenski S (Working Group on Functional Outcome Measures for Clinical Trials).  Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):160-4. No abstract available. PMID: 18314451

Fallin MD, Matteini A. Genetic Epidemiology in Aging. Journals of Gerontology Medical Science. 2008 (In Press)

Leng SX, Huang Y, Fried LP. Frailty and molecular inflammation in older adults. 2007. Long-Term Care Interface (In press)

Matteini AM, Walston JD, Fallin MD, Bandeen-Roche K, Kao WHL, Semba RD, Allen RH, Guralnik J, Fried LP, Stabler SP. Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging. 2008 May;12(5):303-8.  PMID: 18443711

Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC. Baseline Serum Cholesterol Is Selectively Associated With Motor Speed and Not Rates of Cognitive Decline: The Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):619-24.

Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2008 May 1. [Epub ahead of print]

Swihart B, Caffo B, Bandeen-Roche K, Punjabi NM (2006).  Characterization of sleep architecture using multi-state and log-linear models.  Journal of Clinical Sleep Medicine.  (In Press).

Szanton, S.L., Allen JK, Seplaki, CL, Bandeen-Roche K, Fried LP.  Frailty and allostatic load in the Women’s Health and Aging Studies.  Biological Research in Nursing.  (In Press)

Varadhan R, Walston J, Cappola AR, Carlson MC, Wand GS, Fried LP.  Higher Levels and Blunted Diurnal Variation of Cortisol in Frail Older Women.  J Gerontol A Biol Sci Med Sci 2008 63: 190-195.

Varadhan R., Roland C. Simple and globally-convergent methods for accelerating the convergence of any EM algorithm. Scand J Statist, 2008 (In press).

Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K. The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):391-8. PMID: 18426963

Xue Q-L, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-space constriction, development of frailty, and the competing risk of mortality: the Women's Health And Aging Study I. Am J Epidemiol. 2008 Jan 15;167(2):240-8. Epub 2007 Sep 28. PMID: 17906296.

Xue Q-L, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. (In Press).