| Overview
Key Accomplishments
Available Resources
Key Personnel Supported Pilot studies: 06/01/2003 – 05/31/2004 (Year 1) Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty” Paulo Chaves, MD, PhD:“Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study”
06/01/2004 – 05/31/2005 (Year 2) Jeremy Walston, MD: “IL-6 Gene Variation and Phenotypes Related to Frailty” Paulo Chaves, MD, PhD: “Heart Rate Variability, Hemoglobin, and Frailty Status in Disabled, Community-Dwelling Older Adults: A Pilot Study within the Women’s Health and Aging Study”
06/01/2005 – 05/31/2006 (Year 3) Ravi Varadhan, PhD: “Evaluating the Role of Glucocorticoid Resistance in Frailty” Michelle Mielke, PhD: “Brain-derived and peripheral lipid levels as predictors of cognitive and physical frailty” Richard Semba, MD, Jeremy Walston, MD: “Selenium supplementation”
06/01/2006 – 05/31/2007 (Year 4) Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty” Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype” Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty”
06/01/2007 – 05/31/2008 (Year 5) Dan Arking, PhD: “Assessment of mitochondrial DNA variation in frailty” Enid Neptune, MD: “Transcriptional analysis of the aged lung phenotype” Erwin Tan, MD: “The Effect of High-Intensity Volunteering on the Risk of Frailty”
07/01/2008-06/30/2009 (Year 6) - Ronald Cohn, MD: "Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration"
- M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
- Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”
07/01/2009-06/30/2010 (Year 7)
- Ronald Cohn, MD: "Role of Increased TGF-beta signaling in age-related impairment of muscle regeneration"
- M. Daniele Fallin, PhD, and Andrew Feinberg, PhD: “The relationship between aggregate and site-specific methylation and frailty among BLSA participants”
- Sean Leng, MD, PhD: “Specific cytokines, IL-6, TNF-a, and TGF-b, regulate CXCL10 and hic-5 expression”
07/01/2010-06/30/2011 (Year 8)
- Yuri Agrawal, MD: "Vestibular dysfunction and clinical implications in frailty"
- Rita Kalyani, MD: “Insulin Resistance, Energy Homeostasis, and Frailty”
- Sevil Yasar, MD, PhD: “The renin-angiotensin system and physical and cognitive frailty”
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OAIC-supported investigator, Peter Abadir, led the effort to identify a novel and fully functional mitochondrial angiotensin system that declines with age (PNAS; Press Release) Johns Hopkins and University of Maryland held a Joint Pepper Centers Biostatistics Symposium on Time To Event Analysis on September 9, 2011 (Joint Pepper Centers Symposium) OAIC-supported investigators, Ronald Cohn and Tyesha Burks, discover losartan protects against loss of old or damaged muscle (Science Translational Medicine; Press Release) OAIC-supported investigator Ravi Varadhan named 2011 Brookdale Leadership in Aging Fellowship Awardee (Brookdale Foundation) Research by Frank Lin (RCDC) and colleagues find hearing loss is prevalent in nearly two thirds of adults aged 70 years and older in the U.S. population. (Journals of Gerontology) |
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