Aging and Health
The Johns Hopkins Center on Aging and Health

Genetics, Genomics and Molecular Core
Overview
Key Accomplishments
Past and Current Projects
Available Resources

Key Personnel

The leadership of the Genetics Core includes:

  • Aravinda Chakravarti, PhD, Core Director, Professor of Medicine in the Institute for Genetic Medicine at Johns Hopkins University School of Medicine
  • Daniele Fallin, PhD, Co-Director (genetic epidemiology), Professor of Epidemiology in the Johns Hopkins Bloomberg School of Public Health
  • Jeremy Walston, MD, Co-Director (clinical medicine), Professor of Geriatric Medicine in the Johns Hopkins University School of Medicine
  • Dan Arking, PhD, Co-Director (genomics), Assistant Professor of Genetics in the Institute for Genetic Medicine at Johns Hopkins University School of Medicine.

Interactions built into the Genetics Core between geneticists, biostatisticians, genetic epidemiologists and geriatricians have facilitated greatly improved access to the latest and most efficient genotyping technology, and to an analytical infrastructure that can be utilized to understand the role of the frailty syndrome in disease presentation and outcomes.

In addition, Genetics Core leaders provide junior investigators and others interested in frailty and aging-related conditions with study design expertise and facilitate access to large populations of older adults with previously measured phenotypic data relevant to frailty.

This helps to facilitate the identification of the genetic causes or risk factors underlying frailty and will directly lead to improved clinical research and treatments, the aims of which include the prevention and amelioration of the premature onset and progression of frailty associated with aging.

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In the News

OAIC-supported investigator, Peter Abadir, led the effort to identify a novel and fully functional mitochondrial angiotensin system that declines with age (PNAS; Press Release)

Johns Hopkins and  University of Maryland held a Joint Pepper Centers Biostatistics Symposium on Time To Event Analysis on September 9, 2011 (Joint Pepper Centers Symposium)

OAIC-supported investigators, Ronald Cohn and Tyesha Burks, discover losartan protects against loss of old or damaged muscle (Science Translational Medicine; Press Release)

OAIC-supported investigator Ravi Varadhan named 2011 Brookdale Leadership in Aging Fellowship Awardee (Brookdale Foundation)

Research by Frank Lin  (RCDC) and colleagues find hearing loss is prevalent in nearly two thirds of adults aged 70 years and older in the U.S. population. (Journals of Gerontology)

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Announcements

Please click here to learn about our Pepper Scholars Program, a monthly collaborative initiative for supported investigators and all interested in ongoing aging research at the Johns Hopkins OAIC.

Please click here for more information about the Frailty Assessment Tool.

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