Johns Hopkins OAIC Publications

Published or In Press:

Arking DE, Fallin DM, Li T, Beamer BA, Xue QL, Fried LP, Chakravarti A, Walston JD. Variation in the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women. Journal of the American Geriatrics Society, 2006; May;54(5):823-6.

Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, Chaves PHM, Zeger SL, Fried LP. Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. J Gerontol Med Sci, 2006 Mar;61(3):262-6.

Bartali B, Frongillo EA, Bandinelli S, Lauretani F, Semba RD, Fried LP, Ferrucci L.  Low nutrient intake is an essential component of frailty in older persons.  J Gerontol: Med Sci. 2006 Jun;61(6):589-93.

Barzilay JI, Blaum C, Moore T, Xue Q-L, Hirsch CH, Walston JD, Fried LP.  Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study. Arch Intern Med 2007; 167(7):635-41.

Beck J, Ferrucci L, Sun K, Walston J, Fried LP, Varadhan R, Guralnik JM, Semba RD.  Low serum selenium concentrations are associated with poor grip strength among older women living in the community.  Experimental Gerontology (In press).

Benke KS, Chase GA, Fallin D.  Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test.  BMC Genet. 2005 Dec 30;6 Suppl 1:S137

Bjornsson HT, Cui H, Guis D, Fallin MD, Feinberg AP.  The New Field of Epigenomics: Implications for Cancer and Other Common Disease Research. Cold Spring Harb Symp Quant Biol. 2004: 69:447-56.

Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 2004 Aug: 20(8):350-8.

Blaum CS, Xue Q-L, Michelon E, Semba RD, Fried LP. The association of obesity and the frailty syndrome in older women. The Journal of the American Geriatrics Society 2005 June; 53(6):927-34.

Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu A.  Clinical Practice Guidelines and Quality of Care for Older Patients with Multiple Comorbid Diseases:  Implications for Pay for Performance.  JAMA, August 10, 2005:294:5:716-724.

Boyd CM, Xue Q-L, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. The American Journal of Medicine, 2005 Nov;118(11):1225-31.

Boyd CM, Weiss CO, Halter J, Han KC, Ershler WB, Fried LP: Framework for Evaluating Disease Severity Measures in Older Adults with Comorbidity. J Gerontol A Biol Sci Med Sci.  2007, Vol. 62A, No. 3, 286–295.

Carlson MC, Helms MJ, Steffens DC, Burke JR, Potter GG,Plassman BL. Mid-life Activity Predicts Risk of Alzheimer’s Disease in Older Male Twin Pairs.  Alzheimer’s and Dementia. (In press)

Carlson MC, Xue QL, Zhou J, & Fried LP.  Declines in executive function precede those in memory in high functioning older women: The Women’s Health and Aging Study II. Neurology. (In press)

Chaves PHM, Carlson MC, Guralnik JM, Ferrucci L, Semba R, Fried LP.  Association of Mild Anemia with Executive Cognitive Function Impairment in Community-Dwelling Older Women: The Women’s Health and Aging Study II.  J Am Geriatr Soc. 2006 Sep;54(9):1429-35.

Chaves PH, Semba RD, Leng SX, Woodman RC, Ferrucci L, Guralnik JM, Fried LP.  Impact of Anemia and Cardiovascular Disease on Frailty Status of Community-Dwelling Older Women: The Women’s Health and Aging Studies I and II.  J Gerontol Med Sci, 2005 June;60A:6:729-735.

Chi PB, Duggal P, Kao WH, Mathias RA, Grant AV, Stockton ML, Garcia JG, Ingersoll RG, Scott AF, Beaty TH, Barnes KC, Fallin MD. Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. Genet Epidemiol. 2006 Nov: 30(7):609-19.

Dayhoff-Brannigan M, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD.  Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community.  J Gerontol Med Sci (In press).

Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, Margolick JB. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci 2007 (In press).

Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD (Interventions on Frailty Working Group).  Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report.  J Am Geriatr Soc. 2004 Apr;52(4):625-34.

Folsom AR, Boland LL, Cushman M, Heckbert SR, Rosamond WD, Walston JD.  Frailty and risk of venous thromboembolism in older adults.  J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):79-82.

Fried LP, Hadley EC, Walston JD, Newman A, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L.  From bedside to bench: research agenda for frailty.  Sci Aging Knowledge Environ. 2005 Aug 3;2005(31):pe24.

Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.  J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63.

Howard C, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD. Oxidative protein damage is associated with poor grip strength among older women living in the community.  Journal of Applied Physiology 2007; Mar 22; [Epub ahead of print]

Kim DH, Lipsitz LA, Ferrucci L, Guralnik JM, Carlson M, Fleisher LA, Fried LP, Chaves PHM. Association of Reduced Heart Rate Variability with Cognitive Impairment in Older Disabled Women in the Community: A Pilot Study in the Women’s Health and Aging Study I.  J Am Geriatr Soc. 2006 Nov;54(11):1751-7.

Leng SX, Xue Q-L, Huang Y, Ferrucci L, Beamer BA, Fried LP, Walston J.  Baseline Total and Specific Differential White Blood Cell Counts and 5-year All-Cause Mortality in Community-Dwelling Older Women. Experimental Gerontology, 2005 Dec, (40):982-987.

Leng SX, Xue Q-L, Huang Y, Semba R, Chaves P, Bandeen-Roche K, Fried LP, Walston J. Total and differential WBC counts and their associations with circulating IL-6 levels in community-dwelling older women. J Gerontol Med Sci, 2005;60A:195-199.

Leng SX, Xue Q-L, Tian J, Walston J, Fried LP. Inflammation and frailty in older women. J. Am. Geri. Soc. 2007 (In press)

Leng SX, Huang Y, Fried LP. Frailty and molecular inflammation in older adults. 2007. Long-Term Care Interface (in press)

Ling SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM.  Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women's Health and Aging Study II. Arthritis Rheum. 2006 Apr 15;55(2): 256-63.

Michelon E, Blaum C, Semba RD, Xue QL, Ricks MO, Fried LP.  Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):600-7.

Nicodemus KK, Liu W, Chase GA, Tsai YY, Fallin MD. Comparison of type I Error for Multiple Test Corrections in Large SNP Studies Using Principal Components Versus Haplotype Blocking Algorithms. BMC Genetics 2005 Dec: 6 Suppl 1:S78.

Rebok GW, Carlson MC, & Langbaum JB.  Training and maintaining memory abilities in healthy older adults:  traditional and novel approaches. Psychology of Aging. (In press)

Roland C., Varadhan R., and Frangakis C.E. Squared polynomial extrapolation methods with cycling: an application to the positron emission tomography problem, Numerical Algorithms (In press).

Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP.  Oxidative stress is associated with increased mortality among older women living in the community.  JAGS (In Press).

Studenski S, Carlson MC, Fillit H, Greenough WT, Kramer A, Rebok GW..  From bedside to bench: does mental and physical activity promote cognitive vitality in late life?  Sci Aging Knowledge Environ 2006. 28; (10): 21.

Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults--The Experience Corps program in Baltimore. J Urban Health. 2006 Sep;83(5):954-69.

Varadhan R, Walston J, Cappola AR, Carlson MC, Wand GS, Fried LP.  Higher Levels and Blunted Diurnal Variation of Cortisol in Frail Older Women.  J Gerontol: Med Sci (In press)

Walston J, Hadley EC, Ferrucci L, Guralnik J, Newman, AB, Studenski S, Ershler W, Harris T, Fried LP.  Research agenda for Frailty in Older Adults: Towards a Better Understanding of Physiology and Etiology. J Am Geriatr Soc. 2006 Jun;54(6):991-1001.

Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q, Ferrucci L, Fried LP, Chakravarti A. IL-6 Gene Variation is not Associated with Increased Serum Levels of IL-6, muscle weakness, or frailty in older women. Experimental Gerontology, 2005; 40:344-352.

Walston J, Xue Q-L, Semba RD, Ferrucci L, Cappola AR, Ricks M, Guralnik JM, Fried LP. Serum Antioxidants, Inflammation, and Mortality in Older Women. American Journal of Epidemiology 2006:Jan1;163(1):18-26.

Wang C-P, Brown CH, Bandeen-Roche K.  Residual Diagnostics for Growth Mixture Models:  Examining the Impact of a Preventive Intervention on Multiple Trajectories of Aggressive Behavior.  Journal of the American Statistical Association, 2005 Sep;100(3):1054-1076.

Yuh DD, Baumgartner WA.  Cardiac Surgery in the Elderly.  In:  Gerstenblith G, ed.  Cardiovascular Disease in the Elderly.  Totowa, NJ, Humana Press, Inc.  2005 June: pp. 179-201.

Under Revision or Submitted:

Alipanah N, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD.  Relationship of antioxidant nutrients with oxidative protein damage among older women living in the community (Submitted).

Bandeen-Roche K, Walston J, Huang Y, Semba RD, Ferrucci L.  Measuring Systemic Inflammatory Regulation in Older Adults: Evidence and Utility.  (Submitted 2007).

Beamer B, Xue Q, Fallin MD, Arking DE, Walston J, Fried LP, Chakravarti A. Vitamin D receptor gene and muscle strength decline in the WHAS. 2006 (Submitted 2007).

Boyd C, Ricks M, Fried LP, Guralnik JM, Xue Q-L, Bandeen-Roche K. Functional Decline and Recovery of Activities of Daily Living among Hospitalized, Disabled Older Women: The Women’s Health and Aging Study I. The Journal of the American Geriatrics Society. (Submitted).

Carlson MC, Rebok GW., Saczynski JS., Glass TA, McGill S., Tielsch J., Frick K., Seeman T., Hill J., & Fried, LP. Experience Corps: Results of a pilot, randomized controlled trial of a senior service program on cognitive function. (Submitted).

Carlson MC, Rebok G, Matteini A, Xue Q, Bandeen-Roche K, Fried LP. Moderate intensity cognitive activity predicts reduced rates of cognitive decline and lower incidence of cognitive impairment: The Women’s Health and Aging Study II. (Under review)

Chang DC, Joyce DL, Shoher A, Yuh DD.  A Simple Index to Predict Likelihood of Skilled Nursing Facility Admission after CABG among Older Patients.  Annals of Thoracic Surgery 2007 (Submitted).

Chaves PHM, Varadhan R, Lipsitz LA, Stein PK, Fleisher LA, Tian J, Guralnik JM, Fried LP.  Heart Rate–Based Approximate Entropy and Frailty Status in Community-Older Women: Insights into Autonomic Dysfunction, Physiologic Complexity, and Clinical Vulnerability.  (Submitted 2007).

Crentsil V, Ricks M, Xue Q-L, Fried LP.  A Pharmacoepidemiologic Study of Community-Dwelling Disabled Older Women: Medication Use and Associated Factors.  J Gerontol: Med Sci. (Submitted March 2007).

De Fanis U, Wang G, Fedarko N, Walston JD, Casolaro V, Leng SX. CCR5+ T-Cell Phenotypes and Frailty in Older Adults.  (Submitted 2007).

Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue Q-L, Leng SX, Beamer B, Walston JD. Glutathione Peroxidase Enzyme Activity in Aging.  Journal of Gerontology  (In revision 2007)

Evans WJ, Bhasin S, Cress C, Espeland MA, Ferrucci L, Fried LP, Gill G, Pahor M, Studenski S (Working Group on Functional Outcome Measures for Clinical Trials).  Functional outcomes for clinical trials in frail older persons: Time to be moving.  (Submitted)

Fallin MD, Matteini A. Genetic Epidemiology in Aging. 2006, invited review for Journals of Gerontology Medical Science.  (Submitted 2007).

Fallin MD, Arking DE, Xue Q-L, Fried LP, Chakravarti A, Walston J.  No relationship between myostatin gene variation and muscle strength in the WHAS. 2006 (Submitted 2007).

Fallin MD, Arking D, Beamer B, Zarfas K, Xue Q-L, Jung E, Matteini A, Fried LP, Chakravarti A, Walston J. Gene Screen for variation related to frailty in the WHAS. 2006. (Submitted 2007).

Fallin MD, Reiner A, Tracy R, Cushman M, Psaty B, Durda P, Walston J. Gene-Gene Interaction Among inflammatory-related genes and risk for frailty in the Cardiovascular Health Study. (Submitted 2007).

Fried LP, Xue Q-L, Cappola A, Chaves PHM, Ferrucci L, Leng SX, Semba RD, Varadhan R, Walston J, Bandeen-Roche K.  Multisystem physiologic abnormalities in frailty: evidence for complex systems biology at the macro level.  Science. (Submitted 2007).

Laffan AM, Xue Q-L, Glass TA, Fried LP. Association of life space mobility and frailty:  Cross-sectional results from the Women’s Health and Aging Study I. The Journal of the American Geriatrics Society.  (Submitted).

Leng SX and L Fried. Frailty and molecular inflammation in older adults. Long-Term Care Interface (submitted 2007.)

Makary MA.  Frailty as a Predictor of Surgical Outcome in Older Patients.  JAMA. (Submitted 2007).

Matteini A, Fallin MD, Walston J, Bandeen-Roche K, Xue Q-L, Fried LP, Stabler S. The relationship between serum homocysteine and frailty in the WHAS. 2006. (Submitted 2007).

Matteini A, Walston J, Arking D, Xue Q-L, Chakravarti A, Fried LP, Stabler S. Genetic variation in homocysteine-related genes and serum homocysteine levels in the WHAS. 2006. (Submitted March 2007).

Matteini AM, Walston JD, Fallin MD, Bandeen-Roche K, Kao WH, Allen RH, Guralnik J, Fried LP, Stabler SP. Functional vitamin B₁₂ deficiency, related metabolite abnormalities and the association with frailty syndrome in older women. (Submitted 2007)

Mielke MM, Xue Q-L, Zhou J, Chaves PHM, Fried LP, Carlson MC. High serum total cholesterol associated with better psychomotor speed over time: The Women’s Health and Aging Study II.  Journal of Gerontology: Medical Sciences (Submitted).

Semba RD, Ricks MO, Ferrucci L, Xue QL, Guralnik JM, Fried LP.  Low serum selenium is associated with anemia among older adults in the United States. European Journal of Clinical Nutrition (Submitted 2007)

Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP.  Oxidative protein damage as an independent predictor of decline in walking speed and severe walking disability among older women living in the community. J Gerontol: Med Sci. (Submitted).

Swihart B, Caffo B, Bandeen-Roche K, Punjabi NM (2006).  Characterization of sleep architecture using multi-state and log-linear models.  Journal of Clinical Sleep Medicine.  (Submitted).

Szanton, SL, Allen JK, Thorpe R., Seeman T, Bandeen-Roche K, Fried LP.  Effect of perceived income inadequacy and allostatic load on mortality in community dwelling older women.  American Journal of Public Health.  (Submitted March 2007)

Szanton, S.L., Allen JK, Seplaki, CL, Bandeen-Roche K, Fried LP.  Frailty and allostatic load in the Women’s Health and Aging Studies.  Journal of Gerontology: Medical Sciences.  (Submitted March 2007)

Walston J, Fallin MD, Cushman M, Psaty B, Tracy R, Durda P, Reiner A. IL-6 gene variation is associated with plasma IL-6 levels and C-reactive Protein levels in the Cardiovascular Health Study. 2006 (Submitted 2007).

Walston J, Fedarko N, Yang H, Leng SX, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K.  The Physical and Biological Characterization of a Frail Mouse Model.  Journal of Gerontology (In revision 2007).

Weiss CO, Seplaki CS, Wolff JL, Kasper JD, Agree EM.  Little evidence of measurement error found in self-selected walking speed recorded while using an assistive device in an observational study of older women. Journal of Clinical Epidemiology. (Under Review 2007).

Weiss CO, Boyd CM, Yu Q, Wolff JL, Leff B.  A portrait of prevalent major disease multimorbidity in older adults.  Journal of the American Medical Association (Under Review 2007).

Xue Q-L, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. (Submitted).

Xue Q-L, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-Space Constriction, Development of Frailty, and the Competing Risk of Mortality: The Women’s Health and Aging Study I.  American Journal of Epidemiology.  (Submitted).

Xue, Q-L, Bandeen-Roche K. Latent variable models with informative missing covariates. (Submitted).