12:00

Welcome and Introductions

Linda P. Fried, M.D., M. P.H.                      

12:15    

Article Review: Woolf SH. The meaning of translational research and why it matters. JAMA. 2008 Jan 9;299(2):211-3.

T1 and T2 translational research and how it applies to the JHU OAIC:

a) T1 - "Bench to Bedside" translation
b) T2 - Integration of results of clinical studies into clinical practice

Jeremy Walston, M.D.

12:45

c) Methodological Issues related to T1 and T2 translation

Qian-Li Xue, Ph.D.

.

1:00

OAIC Clinical Translation Unit, and CTSA Collaboration: what intervention research infrastructure is available?

Gary Gerstenblith, M.D.,
Paulo Chaves, M.D., Ph.D

1:30

Discussion: What current projects are ready for intervention development?

Facilitator:
Karen Bandeen-Roche, Ph.D.

2:00

Break

2:15

Introduction: Sleep as a Model for Multisystemic, Frailty-Related Interventions

Jeremy Walston, M.D.

2:30 

Sleep Disorders in Frail, Older Adults and Potential for Interventions

Naresh Punjabi, M.D., Ph.D.

3:00

The Impact of Sleep Disorders on Frailty-Related Systems (10 minute presentations):

a) Sleep and Cognition

Michelle Carlson, Ph.D.

b) Sleep and Immune Response/Inflammation

Sean Leng, M.D., Ph.D.

c) Sleep and HPA Axis/Autonomic Dysfunction

Ravi Varadhan, Ph.D.

d) Sleep and Energy Metabolism

Carlos Weiss, M.D., M.H.S.

e) Sleep and Systems Biology Models

Chris Seplaki, Ph.D.

.

Facilitator:

4:15

Summary Discussion:
-Summary of highest-priority intervention development related to sleep and frailty
-Identification of other models for intervention that would impact frailty and multiple systems
-Operational Planning for next steps

Karen Bandeen-Roche, Ph.D.

5:00 

Adjourn