Publications

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA Adducts in lungs Thimmulappa, R.K., Rangasamy, T. , Alam, J., Biswal, S. (2008) Med. Chem. (In press)

Kensler, T.W., Wakabayashi, N., Biswal, S. Cell survival responses to Environmental Stresses via the Keap1-Nrf2-ARE pathway. (2007) Ann. Rev. Pharmacol. Toxicol. 47:6. 1-6.28 PDF

Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. (2007) Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. Am J Respir Crit Care Med. 176(12):1222-35.

McGrath-Morrow S, Rangasamy T, Cho C, Susson T, Neptune E, Wise R, Tuder RM, Biswal S. (2007) Impaired Lung Homeostasis in Neonatal Mice Exposed to Cigarette Smoke. AJRCMB, (In press).

Misra V, Lee H, Singh A, Huang K, Thimmulappa RK, Mitzner W, Biswal S, Tankersley CG. (2007) Global Expression Profiles from C57BL/6J and DBA/2J Mouse Lungs to Determine Aging-related Genes. Physiol. Genomics. 31(3):429-40.

Shin S, Wakabayashi N, Misra V, Biswal S, Lee GW, Agoston ES, Yamamoto M, and Kensler TW. (2007) NRF2 modulates AHR signaling: influence on adipogenesis. Mol Cell Biol 20:7188-97

Thimmulappa R, Fuchs R, Malhotra D, Scollick C, Traore K, Bream J, Trush M, Liby K, MB S, Kensler T, and Biswal S. (2007) Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal 9:1963-70.

Biswal S, and Remick DG. (2007) Sepsis: Redox Mechanisms and Therapeutic Opportunities. Antioxid Redox Signal 9:1959-62.

Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP.Deficiency in Nrf2-GSH Signaling Impairs Type II Cell Growth and Enhances Sensitivity to Oxidants. Am J Respir Cell Mol Biol. 37(1):3-8.

Rulli SJ Jr, Hibbert CS, Mirro J, Pederson T, Biswal S, Rein A. (2007) Selective and non-selective packaging of cellular RNAs in retrovirus particle J Virol. 81(12):6623-31.

Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW , Yamamoto M, Biswal S, Dor´e S (2007)Role of Nrf2 in Protection against Intracerebral Hemorrhage Injury in Mice. Free Radic Biol Med. 102(4):1632-9.

Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Dore S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. (2007)Neuroscience. 147(1):53-9.

Huang K, Rabold R, Schofield B, Mitzner W, Lee H, Biswal S, Tankersley CG. Variation in Senescent-dependent Lung Changes in Inbred Mouse Strains (2007) J Appl Physiol. 102(4):1632-9. PDF

Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald RS, Shirahata M. A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol. 2007 2(3):L704-15. PDF

Thimmulappa, R.K, Lee,H., Rangasamy,T., Kensler,T.W., Yamamoto,M., Reddy, S. P., and Biswal,S., Nrf2 is a critical regulator of innate immune response and survival during experimental sepsis. (2006) J. Clin. Invest. 116, 984-995. PDF

Singh, A., Misra, V.,Thimmulappa, R.K., Lee,H., Ames, S., Hoque, M.O., Herman, J.G., Baylin, S.B., Sidransky, D., Gabrielson, E., Brock, M.V., Biswal, S., Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer. (2006) PLoS Medicine 3(10): e420 PDF

Singh, A., Rangasamy, T., Thimmulappa, R.K., Lee, H., Osburn, W.O., Brigelius-Flohe, R., Kensler, T. W., Yamamoto, M., Biswal, S. Glutathione Peroxidase 2, the Major Cigarette Smoke-inducible Isoform of GPX in Lungs is Regulatd by Nrf2. (2006) Am J Respir Cell Mol Biol. 35(6):639-650. PDF

Thimmulappa, R.K, Scollick, C., Trarore, K., Yates, M., Trush M.A., Liby K.T., Spoorn, M., Yamamoto, M., Kensler,T.W and Biswal,S., Nrf2 dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun (2006) 351, 883-889. PDF

Mensah, G.K., Misra,V. Biswal, S., Ethanol Sensitivity: A Central Role for CREB Transcription Regulation in the Cerebellum Acquaah- BMC-genomics (2006) 7: 308

Osburn, W.O., Wakabayashi, N. Misra, V., Nilles, T., Biswal, S., Trush, M.A., Kensler, T.W. Nrf2 regulates an adpative response protecing against oxidative damage following diquat-mediated formation of superoixide anion. Arch Biochem Biophys. 2006 454 (1): 7-15

Biswal, S., Rangasamy, T., Tuder, R.M., (2006) Modifier Role of NrF2 in Cigarette Smoke-induced Emphysema. Proc Am Thorac Soc 3:543a

Yosida,T., Rangasamy,T., Biswal,S., Petrache,I., Mett, I., et al. (2006) Role of RTP 801, a Suppressor of the mTOR Pathway, in Cigarette Smoke-induces Pulmonary Injury in Mice. Proc Am Thorac Soc 3:55 1a2

Tuder RM, Yoshida T, Fijalkowka I, Biswal S, Petrache I. (2006) Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proc Am Thorac Soc. 2006 3:673-9

Balbir, A., Lee, H., Okumura, M., Biswal, S., Fitzgerald, R. S., and Shirahata, M. A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J. Physiol Lung Cell Mol Physiol (2006) In press

Rangasamy,T., Guo,J., Mitzner,W.A., Roman,J., Singh,A., Fryer, A.D., Yamamoto,M., Kensler,T.W., Tuder,R.M., Georas, S.N., and Biswal, S. Disruption of Nrf2 Enhances Susceptibility to Severe Airway Inflammation and Asthma in Mice. J. Exp Med 202(1):47-59 (2005) PDF

Chen H, Rubin E, Zhang H, Chung S, Jie CC, Garrett E, Biswal S, Sukumar S. Identification of transcriptional targets of HOXA5. J Biol Chem. 280(19):19373 (2005)

Tian,J., Ishibashi,K., Ishibashi,K., Reiser,K., Grebe,R., Biswal,S., Gehlbach,P., Handa, J.T., Advanced Glycation Endproduct-Induced Aging of the Retinal Pigment Epithelium and Choroid: A Comprehensive Transcriptional Response. Proc Natl Acad Sci U S A 11846-11851(2005)

Multilab comparisons of microarray platforms. Irizarry, R., Warren, D., Spencer, F, Kim, I. F., Biswal, S., Frank, B.C., Gabrielson, E., Garcia, J.G.N., Geoghegan, J., Germino, G.,Griffin, C., Hilmer, S.C., Hoffman, E., Jedlicka, A.E., Kawasaki, E., Martinez-Murillo, F., Morsberger, L., Lee, H., Petersen, D., Quackenbush, J., Scott, A., Wilson, M., Yang, Y., Ye, S.Q., Yu,W. Nature methods 2, 345-350 (2005)

Rangasamy,T, Cho,C.Y., Thimmulappa, R.K., Zhen,L, Srisuma,S., Kensler,T.W., Yamamoto,M., Petrache,I, Tuder,R.M. and Biswal, S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice, J.Clin.Invest. 114:1248-1259 (2004) PDF

Biswal, S., Maxwell, T.,Rangasamy,T., Kehrer, J.P. Modulation of benzo[a]pyrene-induced p53 DNA activity by acrolein. Carcinogenesis, 24:1401-1406 (2003)

S. Srisuma, S. Biswal, W. A. Mitzner, S. J. Gallagher, K. H. Mai and E. M. Wagner Identification of genes promoting angiogenesis in mouse lung by transcriptional profiling Am J Respir Cell Mol Biol. 29(2):172-179 (2003)

Wu, XL, Biswal, S. and Kehrer, J. P. Roles of 5-lipoxygenase activating protein in cell proliferation and apoptosis, Cell Biology and Toxicology, 19(3):135-43 (2003)

Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto,M. and Biswal,S. Identification of Nrf2 regulated genes induced by the chemopreventive agent Sulforaphane by oligonucleotide microarray. Cancer Res. 62,5196-5203 (2002) PDF

Biswal, S.S., Mensah G.K., Datta, K., Wu, X.L., and Kehrer, J.P. Inhibition of cell proliferation and AP-1 activity by acrolein in human A549 lung adenocarcinoma cells due to thiol imbalance and covalent modifications. Chem. Res. Toxicol.15(2):180-186 (2002)

Rangasamy T., K. R. T., Mai K. H., and Biswal S. Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells Toxicol Lett, 132 (1) 27-36 (2002)

Biswal, S.S., Datta, K. and Kehrer, J.P. Association between bcl-xl and 5-lipoxygenase activating protein (FLAP) levels in IL-3 dependent FL5.12 cells. Toxicology-160(1-3):97-103 (2001)

Kehrer, J.P., Biswal, S.S., Thuillier, P., Datta, K., Fischer, S. and Vanden Heuvel, J.P. Inhibition of Peroxisome Proliferator Activated Receptor alpha (PPARa) by MK886. Biochem. J. 356 (3) 899-906 (2001).

Datta, K., J.C. Kern, S.S. Biswal, and J.P. Kehrer. Proteolytic Loss of bcl-x(L) in FL5.12 Cells Undergoing Apoptosis Induced by MK886. Toxicol Appl Pharmacol 174:273-281 (2001).

Kehrer, J.P. and Biswal, S.S. Molecular effects of Acrolein. Toxicol. Sci. 57, 6-15 (2000)

Biswal, S.S., Datta, K., Acquaah-Mensah, G.K. and Kehrer, J.P. Changes in ceramide, sphingomyelin and p53 following fludarabine treatment of human chronic B-cell leukemia cells. Toxicology 154: 45-53 (2000).

Biswal, S.S., Datta, K., Shaw, S.D., Feng, X., Robertson, J.D. and Kehrer, J.P. Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicol. Sci. 53, 77-83 (2000).

Horton, N.D., Biswal, S.S., Corrigan, L.L., Bratta, J. and Kehrer, J.P. Acrolein causes Inhibitor kB-independent decreases in Nuclear factor-kB activation in human lung adenocarcinoma (A549) cells. J. Biol. Chem. 274 : 9200-9206 (1999).

Datta K, Biswal, S.S., Kehrer JP. The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem. J. 340, 371-375 (1999).

Robertson, J.D., Datta, K., Biswal, S.S., and Kehrer, J.P. HSP70 antisense oligomer enhances proteasome inhibitor-induced apoptosis. Biochem. J. 344,477-485(1999).

Datta, K., Biswal, S.S., Xu, J., Towndrow, K.M., Feng, X. and Kehrer, J.P. A relationship between 5-lipoxygenase activating protein (FLAP) and bcl-xL expression in murine pro B-lymphocytic FL5.12 cells. J. Biol. Chem. 273: 28163-28169 (1998)

Ahn Y.T., Wu X.L., Biswal S., Velmurugan S., Volkert F.C., and Jayaram, M. The 2micron-plasmid-encoded Rep1 and Rep2 proteins interact with each other and colocalize to the Saccharomyces cerevisiae nucleus. J. Bacteriol. 179: 7497-506 (1997).

Biswas, S., Bhelwa, A., Itoop, A., Biswal S. and Nath, N. In vitro effect of a diabetic serum factor on generation of superoxide free readical, its quenching ability and lysosomal degranulation in normal polymorphonuclear leucocytes. Ind. J. Clin Biochem. 9(2):3-8 (1994).

Biswas, S., Bhelwa, A., Itoop, A., Biswal S. and Nath, N. Effect of diabetic serum factor on polymorphonuclear leukocyte membrane hydrophobicity and particle internalization. Ind. J. Clin. Biochem. 9(1):9-15 (1994).

Nath N, Biswas S, Bhelwa A, Itoop A, and Biswal S. Plausible involvement of a diabetic serum factor in neutrophil membrane pathology. Ind. J. Biochem. Biophys. 30, 244-246 (1993).